Pittsburgh scored a convincing 41-10 win over San Francisco at home in Preseason Week 3. The Steelers quickly took control of the game, jumping to a 10-0 lead in the first quarter. Michael Turner opened the scoring with a 47-yard field goal at 8:53. Just over four minutes later, Joe Lockwood connected with Vincent Cashwell for an 11-yard touchdown pass. The extra point by Turner was good, putting Pittsburgh up 10-0.

San Francisco responded late in the first quarter with a 27-yard field goal by Joseph Dugan, cutting the lead to 10-3. However, Pittsburgh's offense continued to dominate in the second half.

Lockwood threw four touchdown passes on 18 completions out of 38 attempts for 213 passing yards. He was also intercepted twice, but Pittsburgh’s rushing game offset the turnovers. The team accumulated 268 rushing yards and four rushing touchdowns, led by Charles Lewis who had 127 rushing and 26 receiving yards. Paul Barry and David Thurman contributed 78 and 31 rushing yards respectively. Thurman also caught a touchdown pass.

Vincent Cashwell stood out with two rushing touchdowns and 32 receiving yards. Rodney Rodriguez added a rushing score on a 44-yard reception.

Pittsburgh's defense pressured San Francisco quarterback Arnold Anaya, sacking him six times and forcing two interceptions. San Francisco managed only 70 passing yards and 38 rushing yards for the game, failing to score a touchdown.

The Steelers executed strong special teams play, including effective punting by Stephen Mizrahi, who pinned San Francisco several times deep in their territory throughout the second quarter.

San Francisco's defense forced one fumble and recovered another but could not translate those opportunities into points beyond the lone field goal.

Pittsburgh's head coach Eric Hess will likely take positives from the balanced offensive attack and strong defensive pressure as the team prepares for the regular season. San Francisco coach Ralph Overall faces a rebuilding task after the one-sided loss.

The Steelers finished without penalties and maintained solid ball control, not facing a single third-down conversion attempt by either team.

This dominant performance by Pittsburgh highlighted their preparation and depth in the preseason, underscoring their intent for a competitive 2072 campaign.